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- Title
EFFECTS OF AMINOGUANIDINE AND WOUND HEALING OF THE RABBIT ON PLASMA ANTIOXIDANT STATUS, PROTEIN OXIDATION, AND INFLAMMATION.
- Authors
KARATAS, F.; YILDIRIM, Z.; AKBULUT, K. G.; OZER, C.; ACARTURK, F.; ERBAS, D.
- Abstract
The aim of the study was to investigate the effects of local application of aminoguanidine (AMG) to oral mucosal wound or systemic administration application of AMG on the protein oxidation and antioxidant parameters and changes of inflammatory cytokines plasma. New-Zealand rabbits (n = 18) were used in the study. A standart incision was applied to the oral mucosa rabbits. Rabbits were divided into three groups as: Untreated incisional group (group I), local polyethylene glycol (PEG)+AMG (12.7 mg) bead (group II), and subcutaneous (sc) AMG administrated group (100 mg/kg for 3 days) (group III). Plasma tumor necrosis factor-α (TNF-α), interferongamma (IFN-γ), advanced oxidation protein products (AOPP) levels and superoxide dismutase (SOD), glutathione peroxidase (GPx) activities were measured. Results showed that SOD and GPx activities in group III were statistically and significantly high compared to the control group (p < 0.05), while TNF-α and IFN-γ levels were significantly lower in groups II and III (p < 0.05). The plasma AOPP levels were decreased in group III when compared to group I. However, this was not a significant difference (p > 0.05). The findings in the present study suggested that subcutaneous/local administration of AMG might improve the wound healing by reducing the levels of protein oxidation and inflammation.
- Subjects
AMINOGUANIDINE; OXIDATION; CYTOKINES; RABBIT anatomy; TUMOR necrosis factors
- Publication
Oxidation Communications, 2016, Vol 39, Issue 4-I, p2938
- ISSN
0209-4541
- Publication type
Article