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- Title
Analysis of Racecadotril in Pharmaceutical Formulations Using Ultra Performance Liquid Chromatography (UPLC) Method.
- Authors
ÖNAL, Armağan; BİNAY, Emrullah
- Abstract
Objective: In this study, a simple and selective ultra-performance liquid chromatography method for the determination of racecadotril in pharmaceutical dosage forms has been developed. Methods: The method is in reverse phase C18 column; based on the chromatographic analysis of racecadotril with acetonitrile-water (70: 30, v/v) mobile phase at a flow rate of 0.7 mL/minimum. Results: The most suitable wavelength for racecadotril has been determined 220 nm. The linearity range for racecadotril was found 5-100 μg/mL. Conclusion: This method was applied to the analysis of racecadotril drug substance in tablets. The results were evaluated statistically. The developed method is easy, precise and repeatable and can be used safely in racecadotril pharmaceutical dosage forms analysis.
- Subjects
LIQUID chromatography; DOSAGE forms of drugs; DRUG tablets; CHROMATOGRAPHIC analysis; DRUG analysis
- Publication
Bezmialem Science, 2023, Vol 11, Issue 3, p289
- ISSN
2148-2373
- Publication type
Article
- DOI
10.14235/bas.galenos.2023.59244