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- Title
Adaptive Immunity, Inflammation, and Cardiovascular Complications in Type 1 and Type 2 Diabetes Mellitus.
- Authors
Pedicino, Daniela; Liuzzo, Giovanna; Trotta, Francesco; Giglio, Ada Francesca; Giubilato, Simona; Martini, Francesca; Zaccardi, Francesco; Scavone, Giuseppe; Previtero, Marco; Massaro, Gianluca; Cialdella, Pio; Cardillo, Maria Teresa; Pitocco, Dario; Ghirlanda, Giovanni; Crea, Filippo
- Abstract
Diabetes mellitus (DM) is a pandemics that affects more than 170 million people worldwide, associated with increased mortality and morbidity due to coronary artery disease (CAD). In type 1 (T1) DM, the main pathogenic mechanism seems to be the destruction of pancreatic β-cells mediated by autoreactive T-cells resulting in chronic insulitis,while in type 2 (T2) DM primary insulin resistance, rather than defective insulin production due to β-cell destruction, seems to be the triggering alteration. In our study, we investigated the role of systemic inflammation and T-cell subsets in T1- and T2DM and the possible mechanisms underlying the increased cardiovascular risk associated with these diseases.
- Subjects
TYPE 1 diabetes; TYPE 2 diabetes; INFLAMMATION; IMMUNITY; CARDIOVASCULAR diseases; DIABETES complications; INSULIN resistance
- Publication
Journal of Diabetes Research, 2013, p1
- ISSN
2314-6745
- Publication type
Article
- DOI
10.1155/2013/184258