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- Title
Further important sensitizers in patients sensitive to fragrances*.
- Authors
Frosch, P. J.; Johansen, J. D.; Menné, T.; Pirker, C.; Rastogi, S. C.; Andersen, K. E.; Bruze, M.; Goossens, A.; Lepoittevin, J. P.; White, I. R.
- Abstract
The aim of this study was to determine the frequency of responses to selected fragrance materials in consecutive patients patch tested in 6 dermatological centres in Europe. 1855 patients were evaluated with the 8% fragrance mix (FM) and 14 other frequently used well-defined fragrance chemicals (series I). Each patient was classified regarding a history of adverse reactions to fragrances: certain, probable, questionable, none. Reactions to FM occurred in 11.3% of the subjects. The 6 substances with the highest reactivity following FM were Lyral® (2.7%), citral (1.1%), farnesol P (0.5%), citronellol (0.4%), hexyl cinnamic aldehyde (0.3%), and coumarin (0.3%). 41 (2.2%) of the patients reacted only to materials of series I and not to FM. 6.6% of 1855 patients gave a history of adverse reactions to fragrances which was classified as certain. This group reacted to FM only in 41.1%, to series I and FM in 12.0% and to series I only in 7.2%. 74.3% of the 39 patients reacting to both FM and 1 of the materials of series I had any type of positive fragrance history, which was significantly higher in comparison to those with isolated reactions to series I (53.6% of 41), p = 0.04. The study identified further sensitizers relevant for patch testing of patients with contact dermatitis, of which Lyral® is the most important single chemical.
- Subjects
EUROPE; PERFUMES; CONTACT dermatitis
- Publication
Contact Dermatitis (01051873), 2002, Vol 47, Issue 2, p78
- ISSN
0105-1873
- Publication type
Article
- DOI
10.1034/j.1600-0536.2002.470204.x