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- Title
The Role of the Column in Preparative HPLC.
- Authors
Majors, Ronald E.
- Abstract
This article presents a discussion of preparative chromatography which focuses on the columns used in preparative high performance liquid chromatography, including how to select the appropriate mode, mobile-phase system and operating conditions. The column is the heart of the liquid chromatograph. Choice of the wrong column and mobile-phase conditions for the sample at hand can trivialize all of the advantages of expensive, sophisticated instrumentation and data systems. In preparative chromatography, this statement is also true. An unsuitable column-mobile-phase combination can be disastrous, with possible sample precipitation wreaking havoc on expensive wide-bore preparative columns and instrumentation.
- Subjects
HIGH performance liquid chromatography; SCIENTIFIC apparatus &; instruments; LIQUID chromatography; CHROMATOGRAPHIC analysis; HIGH pressure (Science); PHYSICS instruments
- Publication
LC-GC Europe, 2004, Vol 17, Issue 10, p512
- ISSN
1471-6577
- Publication type
Article