We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Monoamine oxidase A is down-regulated in EBV-associated nasopharyngeal carcinoma.
- Authors
Lee, Hui Min; Sia, Alice Pei Eal; Li, Lili; Sathasivam, Hans Prakash; Chan, Melissa Sue Ann; Rajadurai, Pathmanathan; Tsang, Chi Man; Tsao, Sai Wah; Murray, Paul G.; Tao, Qian; Paterson, Ian C.; Yap, Lee Fah
- Abstract
Nasopharyngeal carcinoma (NPC) is a highly metastatic cancer that is consistently associated with Epstein-Barr virus (EBV) infection. In this study, we identify for the first time a role for monoamine oxidase A (MAOA) in NPC. MAOA is a mitochondrial enzyme that catalyzes oxidative deamination of neurotransmitters and dietary amines. Depending on the cancer type, MAOA can either have a tumour-promoting or tumour-suppressive role. We show that MAOA is down-regulated in primary NPC tissues and its down-regulation enhances the migration of NPC cells. In addition, we found that EBV infection can down-regulate MAOA expression in both pre-malignant and malignant nasopharyngeal epithelial (NPE) cells. We further demonstrate that MAOA is down-regulated as a result of IL-6/IL-6R/STAT3 signalling and epigenetic mechanisms, effects that might be attributed to EBV infection in NPE cells. Taken together, our data point to a central role for EBV in mediating the tumour suppressive effects of MAOA and that loss of MAOA could be an important step in the pathogenesis of NPC.
- Subjects
MONOAMINE oxidase; NASOPHARYNX cancer; METASTASIS; EPSTEIN-Barr virus; AMINES; MITOCHONDRIAL enzymes
- Publication
Scientific Reports, 2020, Vol 10, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-020-63150-0