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- Title
Risk Factors for the Development of Nontuberculous Mycobacteria Pulmonary Disease during Long-Term Follow-Up after Lung Cancer Surgery.
- Authors
Kim, Bo-Guen; Choi, Yong Soo; Shin, Sun Hye; Lee, Kyungjong; Um, Sang-Won; Kim, Hojoong; Cho, Jong Ho; Kim, Hong Kwan; Kim, Jhingook; Shim, Young Mog; Jeong, Byeong-Ho
- Abstract
The aim of this study is to determine the cumulative incidence of, and the risk factors for, the development of nontuberculous mycobacteria pulmonary disease (NTM-PD) following lung cancer surgery. We retrospectively analyzed patients with non-small cell lung cancer who underwent surgical resection between 2010 and 2016. Patients who met all the diagnostic criteria in the NTM guidelines were defined as having NTM-PD. Additionally, we classified participants as NTM-positive when NTM were cultured in respiratory specimens, regardless of the diagnostic criteria. We followed 6503 patients for a median of 4.89 years, and NTM-PD and NTM-positive diagnoses occurred in 59 and 156 patients, respectively. The cumulative incidence rates of NTM-PD and NTM-positive were 2.8% and 5.9% at 10 years, respectively. Mycobacterium avium complex was the most commonly identified pathogen, and half of the NTM-PD patients had cavitary lesions. Several host-related factors (age > 65 years, body mass index ≤ 18.5 kg/m2, interstitial lung disease, bronchiectasis, and bronchiolitis) and treatment-related factors (postoperative pulmonary complications and neoadjuvant/adjuvant treatments) were identified as risk factors for developing NTM-PD and/or being NTM-positive after lung cancer surgery. The incidences of NTM-PD and NTM-positive diagnoses after lung cancer surgery were not low, and half of the NTM-PD patients had cavitary lesions, which are known to progress rapidly and often require treatment. Therefore, it is necessary to raise awareness of NTM-PD development after lung cancer surgery.
- Subjects
LUNG surgery; LUNG diseases; LUNG cancer; NON-small-cell lung carcinoma; MYCOBACTERIA; ONCOLOGIC surgery; TUBERCULIN test
- Publication
Diagnostics (2075-4418), 2022, Vol 12, Issue 5, pN.PAG
- ISSN
2075-4418
- Publication type
Article
- DOI
10.3390/diagnostics12051086