The article presents a case study of an 80-year-old female who was first admitted for papillary thyroid carcinoma and underwent a total thyroidectomy in 2008. She developed a neck node metastasis in October 2010, as confirmed by excision biopsy. In January 2011, the patient was presented with enlarged palpable and deep neck nodes. The papillary thyroid cancer metastases and loss of the sodium/iodide symporter by the thyroid cancer cells is discussed.