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- Title
Frequency and prognostic value of cutaneous molecular residual disease in mycosis fungoides: a prospective multicentre trial of the Cutaneous Lymphoma French Study Group.
- Authors
Hurabielle, C.; Ingen ‐ Housz ‐ Oro, S.; Ortonne, N.; Cornillet ‐ Lefèbvre, P.; Merah, A.; D'Incan, M.; Joly, P.; Franck, N.; Estève, E.; Maubec, E.; Grange, F.; Machet, L.; Laroche, L.; Barete, S.; Dalac, S.; Mortier, L.; Michel, C.; Quereux, G.; Saiag, P.; Ram ‐ Wolff, C.
- Abstract
Background Monoclonal T-cell receptor (TCR) rearrangement is detected in 57-75% of early-stage mycosis fungoides (MF) at diagnosis. A retrospective study showed molecular residual disease (MRD) in 31% of patients in complete clinical remission (CR) after 1 year of treatment. Objectives To confirm the frequency of MRD at 1 year and to determine its prognostic value for further relapse. Methods Patients with T1-, T2- or T4-stage MF were prospectively included in this multicentre study. At diagnosis, clinical lesions and healthy skin were biopsied. After 1 year of topical treatment, previously involved skin of patients in CR was biopsied for histology and analysis of TCR-γ gene rearrangement. The results were compared with the clinical status each year for 4 years. Results We included 214 patients, 133 at T1, 78 at T2 and three at T4 stage. At diagnosis, 126 of 204 cases (61·8%) showed TCR clonality in lesional skin. After 1 year, 83 of 178 patients (46·6%) still being followed up were in CR and 13 of 63 (21%) showed MRD. At 4 years, 55 of 109 patients (50·5%) still being followed up were in CR and 44 of 109 (40·4%) were in T1 stage. MRD did not affect clinical status at 4 years (CR vs. T1/T2, P = 1·0; positive predictive value 36·4%; negative predictive value 67·6%). Conclusions T-cell clonality at diagnosis and MRD at 1 year are not prognostic factors of clinical status at 4 years.
- Subjects
T cell receptors; MYCOSIS fungoides; SKIN cancer; LYMPHOMAS; DISEASE relapse
- Publication
British Journal of Dermatology, 2015, Vol 173, Issue 4, p1015
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/bjd.14017