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- Title
Famotidine prevents canine gastric blood flow reduction by NSAIDs.
- Authors
Hata, J.; Kamada, T.; Manabe, N.; Kusunoki, H.; Kamino, D.; Nakao, M.; Fukumoto, A.; Yamaguchi, T.; Sato, M.; Haruma, K.
- Abstract
: To investigate the effect of famotidine on gastric blood flow reduction induced by diclofenac sodium, a common non-steroidal anti-inflammatory drug in Japan, using laser Doppler flowmetry in the canine stomach.: The gastric mucosal blood flow was measured by laser Doppler flowmetry in 15 healthy male beagles before and 60 min after the administration of diclofenac suppository (1.0 mg/kg) into the rectum. The examination was done in a crossover, single-blinded fashion. All dogs underwent both famotidine (0.5 mg/kg) and placebo (saline) injection simultaneously with the administration of diclofenac. In addition, the tissue concentration of prostaglandin E2 was measured.: The blood flow decreased by 18.3 ± 9.1% in the gastric body, by 26.3 ± 8.1% in the antrum in the placebo group after the administration of diclofenac sodium, while the decreases seen were significantly smaller in the famotidine group: 3.2 ± 12.6% in the gastric body and 7.9 ± 16.5% in the antrum (P = 0.001 for the gastric body,P = 0.0034 for the antrum). Conversely, the percentage of mucosal prostaglandin E2 concentration decrease in each group did not show a significant difference.: Famotidine alleviates the reduction of gastric blood flow induced by diclofenac sodium. Further, not only mucosal prostaglandins but also gastric acid may play an important role in non-steroidal anti-inflammatory drugs-induced gastric microcirculatory disturbance.
- Subjects
BLOOD flow; ANTI-inflammatory agents; HEMODYNAMICS; PLACEBOS; GASTRIC acid; SODIUM
- Publication
Alimentary Pharmacology & Therapeutics, 2005, Vol 21, p55
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/j.1365-2036.2005.02475.x