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- Title
Hypoacidity combined with high gastric juice nitrite induced by Helicobacter pylori infection is associated with gastric cancer.
- Authors
Shiotani, A.; Iishi, H.; Uedo, N.; Higashino, K.; Kumamoto, M.; Nakae, Y.; Tatsuta, M.
- Abstract
: In patients with Helicobacter pylori infection, the concentration of nitrite in gastric juice is elevated. The degree of elevation correlates with that of inflammation and H. pylori density. : The aim of this study was to examine hypoacidity and high nitrite levels related to H. pylori infection in patients with gastric cancer. : We studied 88 patients with more than one history of endoscopic mucosal resection (EMR) for early gastric cancer and 88 age-matched controls. Concentration of nitrite in gastric juice was measured by Griess reaction, and serum pepsinogen levels were measured by RIA. : Multiple malignant lesions were found in 20 of the 88 patients. Serum gastrin, gastric juice pH and nitrite levels in patients with gastric cancer were significantly higher and pepsinogen I and pepsinogen I/II significantly lower than in control subjects. Pepsinogen I level and I/II ratio were lower and gastric juice pH was higher in the protruded-type group than in the depressed-type group. Pepsinogen I and pepsinogen I/II were lower and gastric juice pH was higher in multiple than in single cases. : Hypoacidity combined with high gastric juice nitrite induced by H. pylori infection is associated with the intestinal type of gastric cancer, especially protruded lesions.
- Subjects
ACHLORHYDRIA; GASTRIC juice; NITRATES; HELICOBACTER pylori infections; STOMACH cancer; INFLAMMATION
- Publication
Alimentary Pharmacology & Therapeutics, 2004, Vol 20, p48
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/j.1365-2036.2004.01978.x