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- Title
A rapid-release 50-mg tablet-based <sup>13</sup> C-urea breath test for the diagnosis of Helicobacter pylori infection.
- Authors
Wong, W. M.; Lam, S. K.; Lai, K. C.; Chu, K. M.; Xia, H. H. X.; Wong, K. W.; Cheung, K. L.; Lin, S. K.; Wong, B. C. Y.
- Abstract
Summary Background : Recently, a rapid-release 100-mg 13 C-urea tablet with citrate supplement (Diabact UBT) showed excellent performance in a European population. Aim : To investigate the accuracy of a 50-mg tablet-based 13 C-urea breath test protocol. Methods : Consecutive dyspeptic patients referred for upper endoscopy were recruited. 13 C-Urea breath test was performed using a 50-mg 13 C-urea tablet (Diabact UBT) and compared with the gold standard (rapid urease test and histology). Baseline, 10-min, 20-min and 30-min breath samples were collected in all cases. The cut-off values at each measurement interval were determined by three standard deviations above the mean excess δ 13 CO2 excretion of Helicobacter pylori -negative patients. Results : Two hundred patients (150 before therapy and 50 after therapy) were available for analysis, with a mean age of 48.4 years, and 99 patients (50%) were H. pylori positive. The sensitivity and specificity of the 50-mg tablet-based 13 C-urea breath test at 10 min, 20 min and 30 min were 100% and 98%, 100% and 100%, and 100% and 98%, respectively. Conclusion : A 20-min, 50-mg tablet-based 13 C-urea breath test (Diabact UBT) protocol is highly accurate for the diagnosis of H. pylori infection.
- Subjects
HELICOBACTER pylori infections; HELICOBACTER pylori
- Publication
Alimentary Pharmacology & Therapeutics, 2003, Vol 17, Issue 2, p253
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1046/j.1365-2036.2003.01417.x