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- Title
Cytologic Features of ALK-Positive Pulmonary Adenocarcinoma.
- Authors
Seung Yeon Ha; Jungsuk Ahn; Mee Sook Roh; Joungho Han; Jae Jun Lee; Boin Lee; Jun Yim
- Abstract
Background: The aim of this study was to determine the cytologic features of anaplastic lymphoma kinase (ALK) expressing pulmonary adenocarcinoma. Methods: We analyzed the cytopathological findings of 15 cases of endobronchial ultrasound guided aspiration and a case of bronchial washing. These cases were selected based on the histomorphology of ALK-rearranged lung adenocarcinoma. Results: Cytology showed mucinous (81.3%) and hemorrhagic (50%) backgrounds. The cells were arranged in tubulopapillary or tubulocribriform patterns (93.8%), and clusters (56.3%) admixed with signet ring cell features (87.5%). The tumor cells were monotonous and uniform with vesicular nuclei and a small nucleolus. Conclusions: The characteristic findings were sheets showing a tubulopapillary or tubulocribriform appearance, with vesicular nuclei and a bland chromatin pattern (p<0.001). Scattered signet ring cells were helpful in suggesting ALK-positive adenocarcinoma (p<0.001).
- Subjects
ADENOCARCINOMA; LUNG diseases; NUCLEOPROTEINS; MEDICAL imaging systems; CANCER cells
- Publication
Korean Journal of Pathology, 2013, Vol 47, Issue 3, p252
- ISSN
1738-1843
- Publication type
Article
- DOI
10.4132/KoreanJPathol.2013.47.3.252