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- Title
Flt3 ligand expands CD4<sup>+</sup> Fox P3<sup>+</sup> regulatory T cells in human subjects.
- Authors
Klein, Oliver; Ebert, Lisa M.; Zanker, Damien; Woods, Katherine; Tan, Bee Shin; Fucikova, Jitka; Behren, Andreas; Davis, Ian D.; Maraskovsky, Eugene; Chen, Weisan; Cebon, Jonathan
- Abstract
CD4+ CD25+ Fox P3+ naturally occurring regulatory T ( Treg) cells play a crucial role in the maintenance of immune tolerance and in preventing autoimmune pathology. Interventions that expand Treg cells are highly desirable, as they may offer novel treatment options in a variety of autoimmune and transplantation settings. Paralleling previous preclinical studies, we demonstrate here that administration of the hematopoietic growth factor Flt3 L to human subjects increases the frequency and absolute number of Treg cells, and reduces the ratio of CD8+ T cells to Treg cells in the peripheral blood. The increase in Treg cells was due to enhanced Treg-cell proliferation rather than release of Treg cells from the thymus. Further studies revealed that Flt3 L-induced proliferation of Treg cells was an indirect effect that occurred via the interaction of Treg cells with the Flt3 L-expanded pool of CD1c+ myeloid dendritic cells. On the basis of these findings, Flt3 L may represent a promising agent for promoting immune tolerance in a variety of clinical settings.
- Publication
European Journal of Immunology, 2013, Vol 43, Issue 2, p533
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.201242603