We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Modified vaccinia Ankara-expressing Ag85A, a novel tuberculosis vaccine, is safe in adolescents and children, and induces polyfunctional CD4.
- Authors
Scriba, Thomas J.; Tameris, Michele; Mansoor, Nazma; Smit, Erica; van der Merwe, Linda; Isaacs, Fatima; Keyser, Alana; Moyo, Sizulu; Brittain, Nathaniel; Lawrie, Alison; Gelderbloem, Sebastian; Veldsman, Ashley; Hatherill, Mark; Hawkridge, Anthony; Hill, Adrian V. S.; Hussey, Gregory D.; Mahomed, Hassan; McShane, Helen; Hanekom, Willem A.
- Abstract
Modified vaccinia Ankara-expressing Ag85A (MVA85A) is a new tuberculosis (TB) vaccine aimed at enhancing immunity induced by BCG. We investigated the safety and immunogenicity of MVA85A in healthy adolescents and children from a TB endemic region, who received BCG at birth. Twelve adolescents and 24 children were vaccinated and followed up for 12 or 6 months, respectively. Adverse events were documented and vaccine-induced immune responses assessed by IFN-γ ELISpot and intracellular cytokine staining. The vaccine was well tolerated and there were no vaccine-related serious adverse events. MVA85A induced potent and durable T-cell responses. Multiple CD4
- Publication
European Journal of Immunology, 2010, Vol 40, Issue 1, p279
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.200939754