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- Title
Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer's disease.
- Authors
Roe, James M.; Vidal-Piñeiro, Didac; Sørensen, Øystein; Brandmaier, Andreas M.; Düzel, Sandra; Gonzalez, Hector A.; Kievit, Rogier A.; Knights, Ethan; Kühn, Simone; Lindenberger, Ulman; Mowinckel, Athanasia M.; Nyberg, Lars; Park, Denise C.; Pudas, Sara; Rundle, Melissa M.; Walhovd, Kristine B.; Fjell, Anders M.; Westerhausen, René; The Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing; Masters, Colin L.
- Abstract
Aging and Alzheimer's disease (AD) are associated with progressive brain disorganization. Although structural asymmetry is an organizing feature of the cerebral cortex it is unknown whether continuous age- and AD-related cortical degradation alters cortical asymmetry. Here, in multiple longitudinal adult lifespan cohorts we show that higher-order cortical regions exhibiting pronounced asymmetry at age ~20 also show progressive asymmetry-loss across the adult lifespan. Hence, accelerated thinning of the (previously) thicker homotopic hemisphere is a feature of aging. This organizational principle showed high consistency across cohorts in the Lifebrain consortium, and both the topological patterns and temporal dynamics of asymmetry-loss were markedly similar across replicating samples. Asymmetry-change was further accelerated in AD. Results suggest a system-wide dedifferentiation of the adaptive asymmetric organization of heteromodal cortex in aging and AD. Cortical thickness is asymmetric, and cortical thinning occurs with age and in disease. Here the authors investigate if both cortices thin at the same rate or if the thicker hemisphere declines faster in aging and in Alzheimer's disease.
- Subjects
ALZHEIMER'S disease; AGE factors in Alzheimer's disease; AGE factors in disease; ADULTS; ENTORHINAL cortex
- Publication
Nature Communications, 2021, Vol 12, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-021-21057-y