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- Title
Atypical lipomatous tumor: retrospective analysis, prognostic factors and MRI in differential diagnosis.
- Authors
Muratori, Francesco; Roselli, Giuliana; Bettini, Leonardo; Frenos, Filippo; D'Arienzo, Antonio; Campanacci, Domenico Andrea; Mondanelli, Nicola; Matera, Davide; Cuomo, Pierluigi; Scoccianti, Guido; Beltrami, Giovanni; Totti, Francesca; Capanna, Rodolfo
- Abstract
Background. Authors analyzed retrospectively 98 Atypical Lipomatous Tumor (ALT) treated at a single institution, 96% of which was localized to the extremities and 4% to the trunk, assessing MRI, surgical treatment, local recurrence, follow-up and de-differentiation ability. Methods. Authors used MRI in order to identify ALT size, site, the presence of septa and contrast enhancement. Surgical margins were divided at final histology in wide/radical, marginal and intralesional. Results. The most common localization was the lower limb (84% of cases), 52% of cases showed size larger than 10 cm; 80% of cases were deep-seated. MRI revealed thick septa in 83% and contrast enhancement in 78% of the cases. Eleven local recurrences of the disease (11%) were observed, with only surgical margins representing a significant prognostic factor on local recurrence (p = 0.0007). No de-differentiation was reported nor metastatic spread. Conclusions. The slow growth and the dedifferentiation ability in ALT needs a long follow-up. MRI with contrast is the imaging method of choice. The optimal treatment is wide/radical resection.
- Subjects
TUMOR diagnosis; MAGNETIC resonance imaging; DIFFERENTIAL diagnosis; TUMOR surgery; TUMOR treatment
- Publication
Clinical Cases in Mineral & Bone Metabolism, 2018, Vol 15, Issue 2, p288
- ISSN
1724-8914
- Publication type
Case Study