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- Title
Phosphoglucomutase comes into the spotlight.
- Authors
Doello, Sofía; Forchhammer, Karl
- Abstract
Glycogen and starch metabolism require the initial synthesis of glucose-1-phosphate (G1P) from glucose-6-phosphate (G6P), a reaction catalysed by the bi-directional enzyme phosphoglucomutase (PGM). Keywords: Cyanobacteria; glycogen; phosphoglucomutase; starch; Synechocystis EN Cyanobacteria glycogen phosphoglucomutase starch Synechocystis 1293 1296 4 03/15/23 20230313 NES 230313 Phosphoglucomutase (PGM) has recently gained attention as a key regulatory point in the metabolism of carbon storage compounds. Overexpression of PGM/PMM reverted the metabolite concentrations to the wild-type levels, confirming that the increased levels of G1P and G6P in the PGM mutant were caused by the low phosphoglucomutase activity of PGM/PMM. In I Synechocystis i , two enzymes are capable of carrying out the phosphoglucomutase reaction: Sll0726 (PGM), which is responsible for 99% of the phosphoglucomutase activity, and Slr1334 (PGM/PMM).
- Subjects
PULLULANASE; MOLECULAR biology; PLANT polymers; GLYCOGEN phosphorylase; BACTERIAL enzymes
- Publication
Journal of Experimental Botany, 2023, Vol 74, Issue 5, p1293
- ISSN
0022-0957
- Publication type
Article
- DOI
10.1093/jxb/erac513