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- Title
Long-term survival among critical care survivors of sepsis in Brazil: a prospective multicenter cohort study.
- Authors
Rosa, Regis Goulart; Kochhann, Renata; Robinson, Caroline Cabral; Schneider, Daniel; Falavigna, Maicon; Sanchez, Evelin Carneiro; de Souza, Denise; Teixeira, Cassiano
- Abstract
Objective: The predictors of sepsis long-term survival are poorly understood. Therefore, we conducted the present study to evaluate factors associated with long-term survival among intensive care unit (ICU) survivors of sepsis in Brazil. Methods: A prospective cohort study was conducted in 10 Brazilian medical-surgical ICUs. Consecutive post-ICU survivors with severe sepsis or septic shock, aged ≥18 years, and with an ICU stay >72h were followed by structured telephone interviews 3, 6, and 12 months after ICU discharge. We evaluated the impact of variables related to the patient pre-ICU health status, ICU treatments and complications, and immediate post-ICU disability on all-cause 12-month mortality. Results: From May 2014 to July 2018, 417 ICU survivors of sepsis were followed. The 12-month all-cause mortality was 33.1% (n=138). After the multivariate Cox regression was performed, age ≥65 years (hazard ratio [HR], 1.60; 95% confidence interval [95%CI], 1.11-2.31), pre-ICU moderate or severe physical dependence according to the Barthel index (HR, 2.30; 95%CI, 1.60-3.30), Charlson comorbidity index ≥2 (HR, 2.09; 95%CI, 1.40-3.14) and the percentage of risk of death at ICU admission (HR, 1.01; 95%CI, 1.003-1.016) were independently associated with all-cause 12-month mortality. Conclusion: Critical care survivors from sepsis with older age, previous physical dependence, higher comorbidity burden and higher severity of acute critical illness are at increased risk for long-term mortality.
- Subjects
COHORT analysis; INTENSIVE care units; SEPSIS
- Publication
Revista Brasileira de Terapia Intensiva, 2018, Vol 30, pS4
- ISSN
0103-507X
- Publication type
Article