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- Title
Synthesis, Spectral Characterization and Analgesic Activity of 2-Methylthio-1,4-Dihydropyrimidines.
- Authors
Sawant, Ramesh; Sarode, Varsha
- Abstract
A series of 2-methylthio-1,4-dihydropyrimidine derivatives (II) were synthesized in good yields by alkylation of 1,2,3,4-tetrahydropyrimidines (I) with methyl iodide in the presence of pyridine. Their structures were conirmed by elemental analysis, IR and ¹H NMR spectra. The compounds were tested for analgesic activity by acetic acid induced writhing method. Compounds IIh, IIe, IIk and IIl showed excellent to good analgesic activity. Other compounds showed moderate analgesic activity. The observed analgesic activity is mainly because of inhibition of the peripheral pain mechanism by the title compounds.
- Subjects
METHYLTHIOADENOSINE; DIHYDROPYRIMIDINE dehydrogenase; ALKYLATION; METHYL iodide; NUCLEAR magnetic resonance spectroscopy; ACETIC acid; PHARMACEUTICAL chemistry
- Publication
Iranian Journal of Pharmaceutical Research, 2011, Vol 10, Issue 4, p733
- ISSN
1735-0328
- Publication type
Article