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- Title
Enterovirus Transmission by Secretory Autophagy.
- Authors
Mutsafi, Yael; Altan-Bonnet, Nihal
- Abstract
Present in many cell types, non-degradative secretory autophagy is a newly discovered pathway in which autophagosomes fuse with the plasma membrane instead of lysosomes. Surprisingly, some viruses exploit secretory autophagy to exit cells non-lytically, shedding into the extracellular environment as particle populations contained within vesicles. As a result, this significantly enhances the infectivity of these viruses. In this paper, this novel cellular exit pathway is highlighted and its advantages for viral transmission discussed.
- Subjects
ENTEROVIRUS diseases; AUTOPHAGY; CELL membranes; POLIOVIRUS; VESICLES (Cytology); RNA viruses
- Publication
Viruses (1999-4915), 2018, Vol 10, Issue 3, p139
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v10030139