We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Assessing the incremental benefit of an extended duration lifestyle intervention for the components of the metabolic syndrome.
- Authors
Walden, Patrick; Qingmei Jiang; Jackson, Elizabeth A.; Oral, Elif A.; Weintraub, Martha S.; Rubenfire, Melvyn
- Abstract
Background: Lifestyle interventions targeting the components of the metabolic syndrome (MetSyn) have been demonstrated to be a cost-effective and suitable treatment strategy for reducing one' s risk of developing coronary artery disease and diabetes. The optimal duration has not yet been defined. We sought to evaluate the incremental benefit of extending a lifestyle intervention from 3 months to 6 months. Methods: We evaluated 114 participants with at least three criteria for the MetSyn in a physician-referred 6-month lifestyle intervention between August 2008 and December 2012. Baseline and follow-up physiological, biochemical, and anthropometric data were analyzed for mean change and incremental change at each time point. Results: The mean age at enrollment was 53.0±10.2 years, and 42% of participants were males. The mean body mass index at enrollment was 38.2±0.86 kg/m² for males and 38.6±0.93 kg/m² for females. Anthropometric measures associated with weight management (body mass index, weight, and body fat percentage) improved significantly with the additional 3-month intervention (P,0.001). Systolic blood pressure (P=0.0001) and diastolic blood pressure (P=0.00006) and triglycerides, fasting blood glucose, and homeostatic model assessment of insulin resistance in diabetic participants (P=0.006, P=0.004, P=0.01, respectively) improved rapidly in the initial 3-month intervention without incremental benefit of the additional 3 months. Improvements in fasting insulin (P=0.01) and homeostatic model assessment of insulin resistance (P=0.02) for nondiabetic participants required the full 6-month intervention before significant reductions were achieved. Conclusion: A 6-month lifestyle intervention yielded significantly better results for variables related to weight management. Standard physiological measures for the MetSyn respond rapidly in a 3-month lifestyle intervention. The long-term impact of an increased duration lifestyle intervention remains to be seen.
- Subjects
DIABETES; PEOPLE with diabetes; UNHEALTHY lifestyles; REGULATION of body weight; METABOLIC syndrome
- Publication
Diabetes, Metabolic Syndrome & Obesity: Targets & Therapy, 2016, Vol 9, p177
- ISSN
1178-7007
- Publication type
Article
- DOI
10.2147/dmso.s94772