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- Title
Alphaherpesviruses and the Cytoskeleton in Neuronal Infections.
- Authors
Zaichick, Sofia V.; Bohannon, Kevin P.; Smith, Gregory A.
- Abstract
Following infection of exposed peripheral tissues, neurotropic alphaherpesviruses invade nerve endings and deposit their DNA genomes into the nuclei of neurons resident in ganglia of the peripheral nervous system. The end result of these events is the establishment of a life-long latent infection. Neuroinvasion typically requires efficient viral transmission through a polarized epithelium followed by long-distance transport through the viscous axoplasm. These events are mediated by the recruitment of the cellular microtubule motor proteins to the intracellular viral particle and by alterations to the cytoskeletal architecture. The focus of this review is the interplay between neurotropic herpesviruses and the cytoskeleton.
- Subjects
HERPESVIRUS diseases; NEURONS; CYTOSKELETON; PERIPHERAL nervous system; EPITHELIUM; DNA replication; PHYSIOLOGY; DISEASES
- Publication
Viruses (1999-4915), 2011, Vol 3, Issue 7, p941
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v3070941