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- Title
Effects of the gut microbiota and its metabolite short-chain fatty acids on endometriosis.
- Authors
Menghe Liu; Ru Peng; Chunfang Tian; Jianping Shi; Jiannan Ma; Ruiwen Shi; Xiao Qi; Rongwei Zhao; Haibin Guan
- Abstract
In recent years, a growing body of research has confirmed that the gut microbiota plays a major role in the maintenance of human health and disease. A gut microbiota imbalance can lead to the development of many diseases, such as pregnancy complications, adverse pregnancy outcomes, polycystic ovary syndrome, endometriosis, and cancer. Short-chain fatty acids are metabolites of specific intestinal bacteria and are crucial for maintaining intestinal homeostasis and regulating metabolism and immunity. Endometriosis is the result of cell proliferation, escape from immune surveillance, and invasive metastasis. There is a strong correlation between the anti-proliferative and anti-inflammatory effects of short-chain fatty acids produced by gut microbes and the development of endometriosis. Given that the mechanism of action of gut microbiota and Short-chain fatty acids in endometriosis remain unclear, this paper aims to provide a comprehensive review of the complex interactions between intestinal flora, short-chain fatty acids and endometriosis. In addition, we explored potential microbial-based treatment strategies for endometriosis, providing new insights into the future development of diagnostic tests and prevention and treatment methods for endometriosis.
- Subjects
SHORT-chain fatty acids; GUT microbiome; MICROBIAL metabolites; ENDOMETRIOSIS; POLYCYSTIC ovary syndrome; PREGNANCY complications; INDUCED ovulation
- Publication
Frontiers in Cellular & Infection Microbiology, 2024, p1
- ISSN
2235-2988
- Publication type
Article
- DOI
10.3389/fcimb.2024.1373004