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- Title
Efficacy of Continuous Positive Airway Pressure on Testosterone in Men with Obstructive Sleep Apnea: A Meta-Analysis.
- Authors
Zhang, Xiao-Bin; Jiang, Xing-Tang; Du, Yan-Ping; Yuan, Ya-Ting; Chen, Bo
- Abstract
Objective: To evaluate the efficacy of continuous positive airway pressure (CPAP) on serum testosterone in men with obstructive sleep apnea (OSA). Methods: Two reviewers independently searched PubMed, Cochrane library, Embase and Web of Science before June 2014. Information on characteristics of subjects, study design, pre- and post-CPAP treatment of serum total testosterone, free testosterone and sexual hormone blinding protein (SHBG) was extracted for analysis. Results: A total of 7 studies with 9 cohorts that included 232 men were pooled into meta-analysis. There was no change of total testosterone levels before and after CPAP treatment in OSA men (standardized mean difference (SMD) = −0.14, 95%CI: −0.63 to 0.34, z = 0.59, p = 0.558), even subdivided by CPAP therapeutic duration (>3 months). Meanwhile, no significant differences in free testosterone and SHBG were detected after CPAP treatment (SMD = 0.16, 95%CI: −0.09 to 0.40, z = 1.25, p = 0.211 and SMD = −0.58, 95%CI: −1.30 to 0.14, z = 1.59, p = 0.112, respectively). Conclusion: CPAP has no influence on testosterone levels in men with OSA, further large-scale, well-design interventional investigation is needed.
- Subjects
CONTINUOUS positive airway pressure; TESTOSTERONE; SLEEP apnea syndromes; TREATMENT effectiveness; BLOOD serum analysis; META-analysis
- Publication
PLoS ONE, 2014, Vol 9, Issue 12, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0115033