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- Title
Shizukaol D Isolated from <i>Chloranthus</i><i> japonicas</i> Inhibits AMPK-Dependent Lipid Content in Hepatic Cells by Inducing Mitochondrial Dysfunction.
- Authors
Hu, Rongkuan; Yan, Huan; Hao, Xiaojiang; Liu, Haiyang; Wu, Jiarui
- Abstract
This study is the first to demonstrate that shizukaol D, a natural compound isolated from Chloranthus japonicus, can activate AMP- activated protein kinase (AMPK), a key sensor and regulator of intracellular energy metabolism, leading to a decrease in triglyceride and cholesterol levels in HepG2 cells. Furthermore, we found that shizukaol D induces mitochondrial dysfunction by depolarizing the mitochondrial membrane and suppressing energy production, which may result in AMPK activation. Our results provide a possible link between mitochondrial dysfunction and AMPK activation and suggest that shizukaol D might be used to treat metabolic syndrome.
- Subjects
PLANT metabolites; PLANT extracts; CYCLIC-AMP-dependent protein kinase; CHLORANTHACEAE; LIVER cells; MITOCHONDRIAL pathology; LIPIDS in the body; ENERGY metabolism
- Publication
PLoS ONE, 2013, Vol 8, Issue 8, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0073527