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- Title
Impact of Serum level of L-Carnitine on Chitotriosidase in Women with Gestational Diabetes Compared to T2DM Pregnant & Non Pregnant Iraqi Women.
- Authors
Hasan, Ali Khalaf; Ali, Shatha H.; Hussein, Wiqar Akram
- Abstract
Background: Gestational diabetes (GDM) was defined as any degree of glucose intolerance that to be first recognized during pregnancy, regardless of the degree of high blood sugar. L-Carnitine appeared to act as a vitamin and thus termed as vitamin BT. Under certain conditions, the demand for carnitine may exceed an individual's capacity to synthesize it, making it a conditionally essential nutrient. Whereas, chitotriosidase is chitinase family member enzyme, produced by activated macro phages. Enzymatic activity of chitotriosidase increases significantly during the development of acute or chronic disorders. Aim: The study involved estimating serum level of L-carnitine & activity of chitotriosidase in women with gestational diabetes compared to type-2 diabetic pregnant & non pregnant Iraqi women. In addition to assessing the possible impact of variations of serum level of carnitine on serum chitotriosidase activity in the study groups. Methodology: This is a case control study included seventy-five women whom attending the Al Alwaiya Maternity Teaching Hospital/Baghdad-Iraq. The participants were selected of similar age consisted of three groups: 25 pregnant women with gestational diabetes, 25 pregnant women with type 2 diabetes, and 25 healthy non pregnant women as a control. After the provision of the ethical approval from Ethics Committee of the Collage of Pharmacy--University of Baghdad. The studied biochemical markers were: total HbA1c, lipid profile, serumL-carnitine & chitotriosidase. Results and Discussion: Data analysis for comparing the groups results (gestational diabetes, T2DM and control) indicated significant variations among them considering serum carnitinelevels & chitotriosidase activity. However, HbA1C levels were positively correlated with L-carnitineamong GDM pregnant women, with highest levels compared to the control & T2DM pregnant women. However, serum carnitine levels were significantly correlated with chitotriosidase activity among GDM pregnants specifically (r=- 0.813,p=0.0001). Conclusion: Serum carnitine level was significantly lowered in T2DM pregnant women,as well as in pregnant women with GDM, as being compared to healthy non pregnant women. Whereas, serum chitotriosidase level were significantly elevated in women with GDM, in comparison to T2DM and controls, it's activity is negatively correlated with serum carnitine level.
- Subjects
IRAQ; RESEARCH; BIOMARKERS; GLYCOSYLATED hemoglobin; CARNITINE; WOMEN; CASE-control method; TYPE 2 diabetes; GLYCOSIDASES; GESTATIONAL diabetes; STATISTICAL correlation
- Publication
Medico-Legal Update, 2020, Vol 20, Issue 4, p1045
- ISSN
0971-720X
- Publication type
Article
- DOI
10.37506/mlu.v20i4.1966