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- Title
Organocatalytic Enantioselective Synthesis of Tetrahydropyridines.
- Authors
Dudognon, Yohan; Rodriguez, Jean; Constantieux, Thierry; Bugaut, Xavier
- Abstract
Tetrahydropyridines are important heterocycles present in many molecules of natural and non‐natural origins that exhibit a wide array of biological activities. With several sp3‐hybridized carbon atoms in their structure, they often include one or several stereogenic centers, whose control represents a great synthetic challenge. For the past two decades, enantioselective organocatalysis has developed as a very powerful strategy to perform the synthesis of enantioenriched compounds, including heterocycles. In this Microreview, we wish to provide the readers with a general overview about the organocatalytic strategies that have been used to achieve the preparation of diversified families of tetrahydropyridines, thereby providing elements of reflection for further developments.
- Subjects
ENANTIOSELECTIVE catalysis; ORGANOCATALYSIS; PYRIDINE synthesis; PYRROLE derivatives; NUCLEOPHILES
- Publication
European Journal of Organic Chemistry, 2018, Vol 2018, Issue 20/21, p2432
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201800236