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- Title
Time-Efficient Synthesis of Pyrido[2,3- d]pyrimidinones via α-Oxoketenes.
- Authors
Castillo, Juan‐Carlos; Quiroga, Jairo; Rodriguez, Jean; Coquerel, Yoann
- Abstract
α-Oxoketene reactive intermediates generated in situ by microwave-assisted Wolff rearrangement of 2-diazo-1,3-dicarbonyl compounds have been found to react with 6-aminopyrimidine derivatives as 1,3-C,N-bis-nucleophiles to yield pyrido[2,3- d]pyrimidinones and related compounds amenable to further functionalization.
- Subjects
PYRIDONE derivatives; CARBONYL compounds; CHEMICAL synthesis; DIAZO compounds; PYRIMIDINE synthesis; PYRIMIDINE derivatives; MICROWAVE chemistry; WOLFF rearrangement; INTERMEDIATES (Chemistry)
- Publication
European Journal of Organic Chemistry, 2016, Vol 2016, Issue 11, p1994
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201600171