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- Title
Expresión de C4d en glomeruloesclerosis focal y segmentaria.
- Authors
Valencia, Venice Chávez; Pérez-Vázquez, Victoriano; García, Anel Gómez; Vargas-Ortiz, Katya; Villanueva Pérez, Martha Arisbeth; Rubí, Marisol Godínez; Villaseñor, Leonardo Pazarín; Castellanos, Sergio Gutiérrez; de la Cruz, Citlalli Orizaga
- Abstract
Background: There is a little information about of expression of C4d (complement fragment) in focal segmental glomerulosclerosis (FSGS) subtypes. Our aim was to determine the expression of C4d in FSGS subtypes in percutaneous native renal biopsies in a second-level hospital and its correlation with clinical, biochemical and histological variables. Material and methods: A retrospective study in paraffin blocks of patients with biopsy with FSGS aged 16-65 years, indistinct sex, not diabetic or obese. Immunohistochemistry was performed for C4d and their expression was analyzing in non-sclerosed glomerular capillaries (GC) and sclerosis areas (SA). Clinical and biochemical variables were recorded. The cases were divided into C4d positive and C4d negative groups and compared. The correlation between C4d staining scores in CG and SA with clinical and biochemical variables were analyzed. Results: Twenty samples were analyzed, 4 for each subtype. At the time of biopsy average age was 38.8 ± 18.6 years, 65% male, 8.7% with hypertension. The percentage of positivity for C4d was 40% in GC, 30% SA and 35% in mesangium. The highest expression was for cellular and collapsing subtypes. C4d positivity cases had increased proteinuria (p = 0.035). A significant correlation was found between percentage of C4d expression in CG with SA (p = 0.012) and SA with tubular atrophy and interstitial fibrosis (p < 0.05). Conclusions: C4d expression in FSGS predominated in the cellular and collapsing subtypes, which translates complement activation. C4d is a possible surrogate marker in GSFS.
- Publication
Nefrologia, 2024, Vol 44, Issue 3, p402
- ISSN
0211-6995
- Publication type
Article
- DOI
10.1016/j.nefro.2023.04.005