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- Title
Severe acute propoxyphene overdose: plasma concentrations of propoxyphene and norpropoxyphene and the effect of dopamine on circulatory failure.
- Authors
Krantz, T.; Thisted, B.; Strøm, J.; Angelo, H. R.; Sørensen, M. Bredgaard; Strøm, J; Sørensen, M B
- Abstract
Twelve patients with cardiovascular failure because of propoxyphene self-poisoning were treated with dopamine. The patients responded favourably to dopamine infusion (2-17 micrograms/kg/min) with a dose-dependent rise in systolic arterial blood pressure and a fall in central venous pressure and copious urinary output. Side effects during infusion were few, and in periods where dopamine infusion exceeded 10 micrograms/kg/min no tachyarrhythmias were seen. Eleven of the patients were treated on a respirator. Two patients were discharged from the ICU with signs of hypoxic brain damage, one of whom recovered completely after 2 weeks. Serum propoxyphene and norpropoxyphene were measured in nine patients. All but one patient had either propoxyphene or norpropoxyphene concentrations above 3 mumol/l.
- Publication
Acta Anaesthesiologica Scandinavica, 1986, Vol 30, Issue 4, p271
- ISSN
0001-5172
- Publication type
journal article
- DOI
10.1111/j.1399-6576.1986.tb02411.x