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- Title
In vitro susceptibility testing of Pityrosporum ovale against antifungal, antiseborrheic and antipsoriatic agents.
- Authors
Nenoff, Pietro; Haustein, Uwe-Frithjof
- Abstract
Objective: The in vitro antimicrobial susceptibitity of Pityrosporwn oz'ale strains isolated from patients with seborrheic dermatitis was determined. Method: Minimum inhibitory concentrations of a total of ii agents - including true antifungal, antiseborrheic, and antipsoriatic drugs - were measured. Results: Ketoconazole was the most effective of the tested antifungal agents against Pityrospo- rum ot'ale in vitro (minimum inhibitory concentration (LI g/m1). The antiseborrheic agents zinc pyrithione and selenium disulfide showed a good in vitro efficacy against Pityrosporwn with similar minimum inhibitory concentrations. Liquor carbonis detergens and dithranol were also able to inhibit growth of Pityrosporum ovate in vitro, but much higher concentrations were necessary. Conclusion: The tested agents commonly used against seborrheic dermatitis might exert their efficacy, at )east in part, due to inhibition of Pityrosporurn ocale.
- Subjects
FERTILIZATION in vitro; MALASSEZIA ovale; MALASSEZIA; ANTIFUNGAL agents; ANTI-infective agents; AZACONAZOLE
- Publication
Journal of the European Academy of Dermatology & Venereology, 1994, Vol 3, Issue 3, p331
- ISSN
0926-9959
- Publication type
Article
- DOI
10.1111/j.1468-3083.1994.tb00371.x