We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Expression patterns of AEG-1 in the normal brain.
- Authors
Kim, Hail; Choi, Minji; Han, Sanghee; Park, Sang-Yoon; Jeong, Myoungseok; Kim, Sang Ryong; Hwang, Eun Mi; Lee, Seok-Geun
- Abstract
Astrocyte elevated gene-1 (AEG-1) is a well-known oncogene implicated in various types of human cancers, including brain tumors. Recently, AEG-1 has also been reported to play pivotal roles in glioma-associated neurodegeneration and neurodegenerative diseases like Parkinson's disease and amyotrophic lateral sclerosis. However, the normal physiological functions and expression patterns of AEG-1 in the brain are not well understood. In this study, we investigated the expression patterns of AEG-1 in the normal mouse brain and found that AEG-1 is widely expressed in neurons and neuronal precursor cells, but little in glial cells. We observed differential expression levels of AEG-1 in various brain regions, and its expression was mainly localized in the cell body of neurons rather than the nucleus. Additionally, AEG-1 was expressed in the cytoplasm of Purkinje cells in both the mouse and human cerebellum, suggesting its potential role in this brain region. These findings suggest that AEG-1 may have important functions in normal brain physiology and warrant further investigation. Our results may also shed light on the differential expression patterns of AEG-1 in normal and pathological brains, providing insights into its roles in various neurological disorders.
- Subjects
AMYOTROPHIC lateral sclerosis; PURKINJE cells; PARKINSON'S disease; BRAIN physiology; NEUROGLIA
- Publication
Brain Structure & Function, 2023, Vol 228, Issue 7, p1629
- ISSN
1863-2653
- Publication type
Article
- DOI
10.1007/s00429-023-02676-1