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- Title
Mammalian cadherins DCHS1-FAT4 affect functional cerebral architecture.
- Authors
Beste, Christian; Ocklenburg, Sebastian; Hagen, Maja; Donato, Nataliya
- Abstract
Cortical development is a complex process where a multitude of factors, including cadherins, plays an important role and where disruptions are known to have far reaching effects in neural development and cortical patterning. Cadherins play a central role in structural left-right differentiation during brain and body development, but their effect on a functional level remains elusive. We addressed this question by examining functional cerebral asymmetries in a patient with Van Maldergem Syndrome (VMS) (MIM#601390), which is caused by mutations in DCHS1- FAT4 cadherins, using a dichotic listening task. Using neurophysiological (EEG) data, we show that when key regulators during mammalian cerebral cortical development are disrupted due to DCHS1- FAT4 mutations, functional cerebral asymmetries are stronger. Basic perceptual processing of biaurally presented auditory stimuli was unaffected. This suggests that the strength and emergence of functional cerebral asymmetries is a direct function of proliferation and differentiation of neuronal stem cells. Moreover, these results support the recent assumption that the molecular mechanisms establishing early left-right differentiation are an important factor in the ontogenesis of functional lateralization.
- Subjects
CADHERINS; BRAIN anatomy; BRAIN physiology; NEURAL development; CELL differentiation; NEUROPHYSIOLOGY; ELECTROENCEPHALOGRAPHY
- Publication
Brain Structure & Function, 2016, Vol 221, Issue 5, p2487
- ISSN
1863-2653
- Publication type
Article
- DOI
10.1007/s00429-015-1051-6