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- Title
Hepatoprotective effects of early pentoxifylline administration on hepatic injury induced by concanavalin A in rat.
- Authors
Mohamed, Doaa Ibrahim; Mohamed Elmelegy, Ahmed Abdel salam; El-Aziz, Lubna Foaad A.; Abdel kawy, Hala Salah; El-Samad, Abeer Ahmed Abd; El-Kharashi, Omnyah Ali
- Abstract
Tumor necrosis factor alpha (TNF-∝) plays an important role in the pathogensis of hepatitis C virus (HCV) infection induced liver injury. This study aimed to evaluate the effects of TNF-∝ inhibition with pentoxifylline (PTX) on concanavalin A (Con A)-induced hepatic injury in rats. The rats were distributed among 3 groups: (i) control group (1 mL saline-week-1 by intravenous injection (i.v.)); (ii) Con A treatment group (20mgCon A-(kgbody mass)-1-week-1, i.v.), and (iii) rats treated with Con A and with PTX (200 mg PTX-(kg body mass)-1-day-1, per oral) group. Blood samples and livers were collected at the end of weeks 1, 2, 4, and 8 of Con A treatment. Portal pressure (PP) was measured at the end of week 8. The administration of PTX was found to confer significant protection against the injurious effects of Con A on the liver, by reducing serum levels of aspartate aminotransferase, alanine aminotransferase, hepatic TNF-∝, and malondialdehyde. Histopathological examination revealed that treatment with PTX significantly suppressed early inflammation, reduced alpha smooth muscle actin, and the apoptosis of hepatocytes induced by Con A. Moreover, PTX significantly (P <0.05) reduced PP, and quantitative analyses of the area of fibrosis induced by treatment with Con A showed a significant reduction at the end of week 8. We conclude that rats treated with PTX revealed a more or less normal hepatocyte architecture as well as marked improvement in fibrosis and PP.
- Subjects
PENTOXIFYLLINE; CONCANAVALIN A; PHARMACODYNAMICS; LIVER injuries; THERAPEUTICS; LABORATORY rats; TUMOR necrosis factors; DIAGNOSIS
- Publication
Canadian Journal of Physiology & Pharmacology, 2014, Vol 92, Issue 6, p490
- ISSN
0008-4212
- Publication type
Article
- DOI
10.1139/cjpp-2014-0085