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- Title
Oral Glutamine Supplement Inhibits Ascites Formation in Peritoneal Carcinomatosis Mouse Model.
- Authors
Ming-Jen Chen; Tsang-En Wang; Shu-Jung Tsai; Ching-Chung Lin; Chia-Yuan Liu; Horng-Yuan Wang; Shou-Chuan Shih; Yu-Jen Chen
- Abstract
Background. Peritoneal carcinomatosis (PC) accompanied with ascites formation causes several distressing symptoms, resulting in poor quality of life. Methods. Twenty BALB/c nude mice generated by direct orthotopic injection of human pancreatic cancer PANC-1 cellswere randomized to receive either a stock laboratory diet or a stock diet supplementedwith glutamine. Half of the mice were sacrificed at day 76 to measure the amount of ascitic fluid and pancreatic tumor volume. The remaining mice were subject to survival analysis. Serum albumin levels were estimated every 2 weeks. Results. At day 76, the average amount of ascitic fluid measured in the control group was 1.2 ± 0.3mL compared to 0.5 ± 0.5mL from the glutamine-supplemented mice (P = 0.045). The volume of pancreatic tumor was 2.60 ± 0.8 cm3 in the control group and 1.98 ± 1.3 cm3 in glutamine-supplemented mice (P = 0.39). The mean survival time of glutamine-supplemented mice was prolonged from 87 ± 4 to 101 ± 2 days (P = 0.0024). Mean serum albumin levels were higher in the glutamine-supplemented group. Conclusions. This preclinical study showed that oral supplementation of glutamine may provide ascites-reducing activity in pancreatic cancer patients with PC, via a cell-mediated immunity-independent mechanism.
- Subjects
ASCITES; PERITONEAL cancer; GLUTAMINE; PSYCHOLOGICAL distress; QUALITY of life; DIETARY supplements; SERUM albumin; THERAPEUTICS; CANCER treatment
- Publication
Gastroenterology Research & Practice, 2013, p1
- ISSN
1687-6121
- Publication type
Article
- DOI
10.1155/2013/814054