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- Title
Lack of Restimulation by Non-HLA Antigens in Primed Lymphocyte Typing.
- Authors
Shih, C.-Y.; Valentine, E. A.; Sheehy, M. J.; Sondel, P. M.; Bach, F. H.
- Abstract
We have studied the role of non-HLA antigens in restimulation of PLT cells by the following protocols. Responder cells were sensitized to cells from family members differing by one HLA haplotype. These PLT cells were restimulated by family members HLA- or HLA-D-identical to the responder. In none of these cases did we find significant restimulation, indicating that it is unlikely that there is a restimulatory non-HLA locus with even two alleles (p < 0.05) of equal frequency. Other protocols we have used are consistent with this interpretation. This indicates that antigens determined by genes segregating independently of HLA do not play a major role in the PLT restimulation.
- Subjects
ANTIGENS; IMMUNOGLOBULINS; HLA histocompatibility antigens; GENES; HEREDITY; FAMILIES
- Publication
Scandinavian Journal of Immunology, 1977, Vol 6, Issue 5, p501
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1977.tb02111.x