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- Title
High prevalence of advanced colorectal neoplasia and serrated polyposis syndrome in Hodgkin lymphoma survivors.
- Authors
Rigter, Lisanne S.; Spaander, Manon C. W.; Aleman, Berthe M. P.; Bisseling, Tanya M.; Moons, Leon M.; Cats, Annemieke; Lugtenburg, Pieternella J.; Janus, Cecile P. M.; Petersen, Eefke J.; Roesink, Judith M.; van der Maazen, Richard W. M.; Snaebjornsson, Petur; Kuipers, Ernst J.; Bruno, Marco J.; Dekker, Evelien; Meijer, Gerrit A.; de Boer, Jan Paul; van Leeuwen, Flora E.; van Leerdam, Monique E.
- Abstract
<bold>Background: </bold>Hodgkin lymphoma (HL) survivors treated with abdominal radiotherapy and/or alkylating chemotherapy have an increased risk of colorectal cancer (CRC). This study was aimed at evaluating the prevalence of colorectal neoplasia in HL survivors.<bold>Methods: </bold>This multicenter cohort study assessed the diagnostic yield of advanced colorectal neoplasia detected by a first surveillance colonoscopy among HL survivors treated with abdominal radiotherapy and/or procarbazine. Advanced colorectal neoplasia included advanced adenomas (high-grade dysplasia, ≥25% villous component, or ≥10-mm diameter), advanced serrated lesions (dysplasia or ≥10-mm diameter), and CRC. The results were compared with those for a Dutch general population cohort that underwent a primary screening colonoscopy (1426 asymptomatic individuals 50-75 years old). This study demonstrated the results of a predefined interim analysis.<bold>Results: </bold>A colonoscopy was performed in 101 HL survivors, who were significantly younger (median, 51 years; interquartile range [IQR], 45-57 years) than the general population controls (median, 60 years; IQR, 55-65 years; P < .001). The prevalence of advanced neoplasia was higher in HL survivors than controls (25 of 101 [25%] vs 171 of 1426 [12%]; P < .001). Advanced adenomas were detected in 14 of 101 HL survivors (14%) and in 124 of 1426 controls (9%; P = .08). The prevalence of advanced serrated lesions was higher in HL survivors than controls (12 of 101 [12%] vs 55 of 1426 [4%]; P < .001). Serrated polyposis syndrome was present in 6% of HL survivors and absent in controls (P < .001).<bold>Conclusions: </bold>HL survivors treated with abdominal radiotherapy and/or procarbazine have a high prevalence of advanced colorectal neoplasia. The implementation of a colonoscopy surveillance program should be considered.
- Subjects
ADENOMATOUS polyps; HODGKIN'S disease
- Publication
Cancer (0008543X), 2019, Vol 125, Issue 6, p990
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/cncr.31903