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- Title
S-Adenosyl-L-Methionine Antagonizes Oral Contraceptive- Induced Bile Cholesterol Supersaturation in Healthy Women: Preliminary Report of a Controlled Randomized Trial.
- Authors
Di Padova, Carlo; Tritapepe, Raffaele; Di Padova, Franco; Frezza, Mario; Stramentinoli, Giorgio
- Abstract
Recent experimental investigations have shown that S-adenosyl-L-methionine (SAMe) reverses estrogen-induced bile secretion impairment. The mechanism of this action seems to be related to the capability of SAMe both to inactivate catecholestrogens by methylation reaction and to methylate membrane phospholipids increasing the liver plasma membrane fluidity reduced by the estrogens. Aim of this investigation was to know whether SAMe also prevents oral contraceptive-induced cholesterol supersaturation of gallbladder bile in humans. To six healthy nonobese women whose bile cholesterol saturation index increased from a mean basal value of 0.77 (SD 0.22) to 1.20 (SD 0.38) (p < 0.01) after two cycles of treatment with oral contraceptives containing 50 µg ethynylestradiol, plus 250 µg d-norgestrel, 200 mg SAMe per os tid was administered in addition to the oral contraceptive for other two cycles. The bile cholesterol saturation index decreased to 0.88 (SD 0.26) (p < 0.05 versus oral contraceptive value). These results indicate that SAMe antagonizes biliary lipid changes induced by estrogen-progestin containing oral contraceptive and suggest its potential usefulness in women on oral contraceptive treatment to prevent lithogenic bile secretion.
- Subjects
ADENOSYLMETHIONINE; BILE; CATECHOL estrogens; METHYLATION; PHOSPHOLIPIDS; CELL membranes; ORAL contraceptives; ETHINYL estradiol; NORGESTREL
- Publication
American Journal of Gastroenterology (Springer Nature), 1984, Vol 79, Issue 12, p941
- ISSN
0002-9270
- Publication type
Article