We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effects of SGLT2 inhibitors on right ventricular function in heart failure patients: Updated meta-analysis of the current literature.
- Authors
Cinar, Tufan; Saylik, Faysal; Cicek, Vedat; Pay, Levent; Khachatryan, Aleksan; Alejandro, Joel; Erdem, Almina; Hayiroglu, Mert Ilker
- Abstract
Background: There is some discrepancy in current studies concerning the effect of sodium-glucose cotransporter type 2 inhibitors (SGLT2i) on right ventricular (RV) functions in heart failure (HF) patients. Hence, this meta-analysis was focused on determining the impact of SGLT2i on RV functions in such individuals. Material and methods: Two independent investigators searched PubMed, Google Scholar, and the Cochrane Library for articles of interest. To analyze heterogeneity, Higgins’ I2 as well as prediction intervals and Egger’s test were used to assess heterogeneity. The Newcastle–Ottawa standard ratings approach was used to assess the quality of observational studies. The ROBINS-I risk of bias algorithm was used to assess bias risks of randomized studies. Results: This meta-analysis evaluated 8 studies in total. Over the follow-up time frame, patients who used SGLT2i had substantially lower systolic pulmonary artery pressure and higher tricuspid annular plane systolic excursion values (mean difference [MD] = –5.23 [–7.81; –2.66] and, MD = 1.47 [1.01; 1.93]; P <0.01, respectively). There was no significant difference in RVS’ values between follow-up and baseline (MD = 1.54 [–0.19; 3.26]; P = 0.08). However, as compared to the baseline period, fractional area contraction values were substantially larger at the end of the follow-up (MD = 5.52 [4.23; 6.82]; P <0.01). Conclusion: To the best of our knowledge, this is the first meta-analysis assessing the impact of SGLT2i on RV function in HF patients. Our findings suggest that SGLT2i may improve RV performance in HF patients.
- Subjects
TRICUSPID valve; PULMONARY artery; HEART failure; HEART physiology; META-analysis; SYSTEMATIC reviews; MEDLINE; SODIUM-glucose cotransporter 2 inhibitors; DRUG efficacy; MEDICAL databases; RIGHT heart ventricle; ONLINE information services; TREATMENT effect heterogeneity; BLOOD pressure; SYSTOLIC blood pressure; PHARMACODYNAMICS; EVALUATION
- Publication
Polish Heart Journal / Kardiologia Polska, 2024, Vol 82, Issue 4, p416
- ISSN
0022-9032
- Publication type
Article
- DOI
10.33963/v.phj.100199