We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Insulin resistance in people living with HIV is associated with exposure to thymidine analogues and/or didanosine and prior immunodeficiency.
- Authors
Høgh, Julie; Hove-Skovsgaard, Malene; Gelpi, Marco; Jensen, Anne Marie Reimer; Gerstoft, Jan; Benfield, Thomas; Storgaard, Heidi; Nielsen, Susanne Dam
- Abstract
<bold>Background: </bold>As people living with HIV (PLWH) are growing older, there is increased incidence of metabolic diseases, including type 2 diabetes mellitus, for which insulin resistance is a key determinant. In this study, we aimed to investigate risk factors associated with insulin resistance in PLWH.<bold>Methods: </bold>We included well-treated PLWH without hepatitis co-infection, and with available fasting serum insulin and plasma glucose (n = 643) from the Copenhagen Comorbidity in HIV Infection Study. Insulin resistance was calculated using the homeostasis model assessment of insulin resistance (HOMA-IR). We investigated the association between risk factors and high HOMA-IR in a logistic regression model adjusted for age, sex, abdominal obesity, smoking status, and origin. When including use of thymidine analogues and/or didanosine in the model, we also adjusted for time with HIV.<bold>Results: </bold>Median (IQR) age of PLWH was 52 years (46-61), and 87% (n = 557) were male. Median (IQR) HOMA-IR was 1.86 (1.23-3.14) mmol/L × mU/L. Risk factors significantly associated with high HOMA-IR included older age, BMI ≥ 25, abdominal obesity, waist circumference, use of thymidine analogues and/or didanosine, time with HIV, and CD4+ nadir < 200 cells/µL.<bold>Conclusions: </bold>Insulin resistance in PLWH is associated with both use of thymidine analogues and/or didanosine and prior immunodeficiency suggesting that increased attention on blood glucose in these patients could be beneficial.
- Subjects
INSULIN resistance; HIV-positive persons; TYPE 2 diabetes; THYMIDINE; METABOLIC disorders; OBESITY complications; HIV infection complications; OBESITY; DEOXYRIBONUCLEOSIDES; DIDANOSINE (Drug); DISEASE complications
- Publication
BMC Infectious Diseases, 2022, Vol 22, Issue 1, p1
- ISSN
1471-2334
- Publication type
journal article
- DOI
10.1186/s12879-022-07485-1