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- Title
Protective Activity of Dendropanax Morbifera Against Cisplatin-Induced Acute Kidney Injury.
- Authors
Kim, Eun-Sun; Lee, Jong Soo; akram, Muhammad; Kim, Kyeong-a; Shin, Young-Jun; Yu, Jong-Hyun; Bae, Ok-Nam
- Abstract
Background/Aims: Drug-induced acute kidney injury (AKI) has been a severe threat to hospitalized patients, raising the urgent needs to develop strategies to reduce AKI. We investigated the protective activity of Dendropanax morbifera (DP), a medicinal plant which has been widely used to treat infectious and pain diseases, on acute kidney injury (AKI) using cisplatin-induced nephropathic models. Methods: Both in vitro renal tubular cells (NRK-52E) and in vivo rat models were used to demonstrate the nephroprotective effect of DP. Results: Methanolic extract from DP significantly reduced cisplatin-induced toxicity in renal tubular cells. Through successive liquid extraction, the extract of DP was separated into n-hexane, CHCl3, EtOAc, n-BuOH, and H2O fractions. Among these, the CHCl3 fraction (DPCF) was found to be most potent. The protective activity of DPCF was found to be mediated through anti-oxidant, mitochondrial protective, and anti-apoptotic activities. In in vivo rat models of AKI, treatment with DPCF significantly reversed the cisplatin-induced increase in blood urea nitrogen and serum creatinine and histopathologic damage, recovered the level of anti-oxidant enzymes, and inhibited renal apoptosis. Conclusion: We demonstrated that DP extracts decreased cisplatin-induced renal toxicity, indicating its potential to ameliorate drug-associated acute kidney damage. © 2015 S. Karger AG, Basel
- Subjects
NEPHROTOXICOLOGY; CISPLATIN; KIDNEY injuries; HOSPITAL care; CANCER chemotherapy
- Publication
Kidney & Blood Pressure Research, 2015, Vol 40, Issue 1, p1
- ISSN
1420-4096
- Publication type
Article
- DOI
10.1159/000368466