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- Title
Evaluation of specific biochemical indicators of Helicobacter pylori-associated gastric cancer in Egypt.
- Authors
Anwar, M. M.; Youssef, A. I.; Sheta, M. I.; Zaki, A.; Bernaba, N. R.; El-Toukhi, M. A.
- Abstract
The aim of the study was to assess the accuracy of some specific biochemical indicators in discriminating between Helicobacter pylori-associated gastritis and H. pylori-associated stomach cancer (serum gastrin level, serum soluble E-cadherin and tissue COX-2 activity, as well as serodiagnostic markers for H. pylori infection) in order to find a simple diagnostic test that can reasonably predict the development of gastric cancer. The study participants comprised 20 patients with gastric carcinoma, 20 patients with positive H. pylori-associated gastritis and 20 individuals as the control group. Standard procedures and quality control measures were followed. Using cut-off values and ROC analysis to assess the diagnostic abilities of the biochemical indicators, E-cadherin showed the highest sensitivity (100%). We suggest that close follow-up together with periodic endoscopic examination for all patients with persistent H. pylori infection and serum soluble E-cadherin level above 5 µg/mL is essential.
- Subjects
EGYPT; ACADEMIC medical centers; ANALYSIS of variance; DIFFERENTIAL diagnosis; GASTRITIS; GLYCOPROTEINS; HELICOBACTER diseases; HELICOBACTER pylori; STATISTICS; STOMACH tumors; T-test (Statistics); TUMOR markers; U-statistics; DATA analysis; DATA analysis software; DESCRIPTIVE statistics; DIAGNOSIS
- Publication
Eastern Mediterranean Health Journal, 2012, Vol 18, Issue 5, p501
- ISSN
1020-3397
- Publication type
Article
- DOI
10.26719/2012.18.5.501