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- Title
Nitrogen metabolism in Mycobacterium tuberculosis physiology and virulence.
- Authors
Gouzy, Alexandre; Poquet, Yannick; Neyrolles, Olivier
- Abstract
Several major pathogens, including Mycobacterium tuberculosis, parasitize host cells and exploit host-derived nutrients to sustain their own metabolism. Although the carbon sources that are used by M. tuberculosis have been extensively studied, the mechanisms by which mycobacteria capture and metabolize nitrogen, which is another essential constituent of biomolecules, have only recently been revisited. In this Progress article, we discuss central nitrogen metabolism in M. tuberculosis, the mechanisms that are used by this pathogen to obtain nitrogen from its host and the potential role of nitrogen capture and metabolism in virulence.
- Subjects
NITROGEN metabolism; MYCOBACTERIUM tuberculosis; MICROBIAL virulence; METABOLITE synthesis; GLUTAMATE dehydrogenase
- Publication
Nature Reviews Microbiology, 2014, Vol 12, Issue 11, p729
- ISSN
1740-1526
- Publication type
Article
- DOI
10.1038/nrmicro3349