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- Title
t(6;8), t(8;9) and t(8;13) translocations associated with stem cell myeloproliferative disorders have close or identical breakpoints in chromosome region 8p11-12.
- Authors
Chaffanet, Max; Popovici, Cornel; Leroux, Dominique; Jacrot, Michèle; Adélaïde, José; Dastugue, Nicole; Grégoire, Marie-José; Hagemeijer, Anne; Lafage-Pochitaloff, Marina; Birnbaum, Daniel; Pébusque, Marie-Josèphe
- Abstract
A stem-cell myeloproliferative disorder involving T- and B-cell, and myeloid lineages, is associated with three different translocations with a breakpoint in region p11-12 of chromosome 8: t(6;8)(q27;p11), t(8;9)(p11;q33), and t(8;13)(p12;q12), respectively. Using fluorescence in situ hybridization (FISH), we have analysed blood cells from a series of five patients carrying these different translocations. We have identified cosmids from chromosome region 8p11-12 that span the breakpoint in all the cases. They are specific for the FGFR1 gene that encodes a receptor for members of the FGF family. The breakpoint was further detected by Southern and pulsed-field gel electrophoresis analyses with probes from the FGFR1 locus.
- Subjects
LEUKEMIA genetics; LYMPHOMAS; CHROMOSOMES; STEM cells; HEMATOPOIESIS
- Publication
Oncogene, 1998, Vol 16, Issue 7, p945
- ISSN
0950-9232
- Publication type
Article
- DOI
10.1038/sj.onc.1201601