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- Title
The Nucleosome-Remodeling ATPase ISWI Is Regulated by Poly-ADP-Ribosylation.
- Authors
Sala1, Anna; La Rocca, Gaspare; Burgio, Giosalba; Kotova, Elena; Di Gesù, Dario; Collesano, Marianna; Ingrassia, Antonia M. R.; Tulin, Alexei V.; Corona, Davide F. V.
- Abstract
ATP-dependent nucleosome-remodeling enzymes and covalent modifiers of chromatin set the functional state of chromatin. However, how these enzymatic activities are coordinated in the nucleus is largely unknown. We found that the evolutionary conserved nucleosome-remodeling ATPase ISWI and the poly-ADP-ribose polymerase PARP genetically interact. We present evidence showing that ISWI is target of poly-ADP-ribosylation. Poly-ADP-ribosylation counteracts ISWI function in vitro and in vivo. Our work suggests that ISWI is a physiological target of PARP and that poly-ADP-ribosylation can be a new, important post-translational modification regulating the activity of ATPdependent nucleosome remodelers.
- Subjects
CHROMATIN; ADENOSINE triphosphatase; ADP-ribosylation; CHROMOSOMES; CELLULAR signal transduction; BIOLOGY
- Publication
PLoS Biology, 2008, Vol 6, Issue 10, p2329
- ISSN
1544-9173
- Publication type
Article
- DOI
10.1371/journal.pbio.0060252