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- Title
An in silico approach to the analysis of CTLA-4 and CD28 molecules.
- Authors
Dilmeç, Fuat; Varışlı, Lokman; Çen, Osman
- Abstract
The CD28 and CTLA-4 are important co-stimulatory molecules expressed on T cells and regulate T cell activation through antigen stimulation. This study aimed to investigate some properties of these genes and its products; such as the homologous protein sequences to human CTLA-4 and CD28 molecules, the common transcription factor binding sites on their promoters, and phylogenetic relationships of their Immunoglobulin V-Type (IGv) domains using bioinformatical approaches. Our results revealed that both CTLA-4 and CD28 molecules are moderately conserved among all organisms investigated. The IGv domains of human CTLA-4 and CD28 are closest to those of Macaca nemestrina, Cercocebus torquatus atys , Macaca mulatta and Papio cynocephalus anubis . In contrast, the IGv domain of CD28 of Gallus gallus and that of CTLA-4 of Mus musculus and Rattus norvegicus is most apart from those of human, respectively. The comparative screening of the promoters revealed that both CTLA-4 and CD28 genes have some conserved transcription factor binding sites.
- Subjects
T cells; PIG-tailed macaque; GENES; PROTEINS; TRANSCRIPTION factors
- Publication
Journal of Cell & Molecular Biology, 2007, Vol 6, Issue 1, p49
- ISSN
1303-3646
- Publication type
Article