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- Title
Hydroaminoalkylation of Allylsilanes and a One-Pot Procedure for the Synthesis of 1,5-Benzoazasilepines.
- Authors
Lühning, Lars H.; Strehl, Julia; Schmidtmann, Marc; Doye, Sven
- Abstract
Allylsilanes undergo highly regioselective intermolecular alkene hydroaminoalkylation with secondary amines in the presence of a titanium mono(formamidinate) catalyst. Corresponding reactions of a suitable allyl(2-bromophenyl)silane which exclusively deliver the branched hydroaminoalkylation products combined with a subsequent Buchwald-Hartwig amination result in the development of an elegant one-pot procedure for the synthesis of literature-unknown silicon analogues of 1,5-benzodiazepines, the so-called 1,5-benzoazasilepines.
- Subjects
BENZENE compound synthesis; ALKYLATION; ALLYLSILANES; AZA compound synthesis; AMINATION; BENZODIAZEPINES; TITANIUM compounds; CATALYSTS
- Publication
Chemistry - A European Journal, 2017, Vol 23, Issue 17, p4197
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201605923