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- Title
Production, quality control, and determination of human absorbed dose of no carrier added <sup>177</sup>Lu-risedronate for bone pain palliation therapy.
- Authors
Salek, Nafise; Mehrabi, Mohsen; Shirvani Arani, Simindokht; Bahrami Samani, Ali; Erfani, Mostafa; Vosoghi, Sara; Ghannadi Maragheh, Mohammad; Shamsaei, Mojtaba
- Abstract
In this study, the radiocomplexation of risedronic acid, a potent bisphosphonate with a no carrier added (NCA) 177Lu, was investigated and followed by quality control studies, biodistribution evaluation, and dosimetry study for human based on biodistribution data in Wistar rats. The moderate energy β− emitter, 177Lu ( T½ = 6.7 days, Eβmax = 497 keV), has been considered as a potential agent for development of bone-seeking radiopharmaceuticals. Because the specific activity of the radiolabeled carrier molecules should be high, the NCA radionuclides have an effective role in nuclear medicine. Many researchers illustrated an NCA 177Lu production; among these separation techniques, extraction chromatography has been considered more capable than other methods. The NCA 177Lu was produced with specific activity of 48 Ci/mg and radionuclidic purity of 99.99% by the irradiation of enriched 176Yb target in thermal neutron flux of 4 × 1013 n·cm−2·s−1 for 14 days. The NCA 177Lu was mixed to a desired amount of sodium risedronate (15 mg/mL, 200 μL) and incubated with stirring at 95°C for 30 minutes. The radiochemical purity of 177Lu-risedronate was determined by radio thin-layer chromatography, and high radiochemical purities (>97%) were obtained under optimized reaction conditions . The complex was injected to Wistar rats, and complex biodistribution was performed 4 hours to 7 days postinjections showing high bone uptake (9.8% ± 0.24% ID/g at 48 hours postinjection). Also, modeling the radiation dose delivery by RADAR software for the absorbed dose evaluation of each human organ showed a major accumulation of the radiocomplex in bone tissue.
- Subjects
PALLIATIVE treatment; CHROMATOGRAPHIC analysis; BONE metastasis; DIPHOSPHONATES
- Publication
Journal of Labelled Compounds & Radiopharmaceuticals, 2017, Vol 60, Issue 1, p20
- ISSN
0362-4803
- Publication type
Article
- DOI
10.1002/jlcr.3466