We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A lavender ABC transporter confers resistance to monoterpene toxicity in yeast.
- Authors
Demissie, Zerihun A.; Tarnowycz, Mike; Adal, Ayelign M.; Sarker, Lukman S.; Mahmoud, Soheil S.
- Abstract
Main conclusion: Functional expression of a multidrug resistance-type ABC transporter from Lavandulaangustifolia improved yeast resistance to geraniol, a monoterpene constituent of lavender essential oil.Plant ATP-binding cassette (ABC) transporters are a large family of membrane proteins involved in active and selective transport of structurally diverse compounds. In this study, we functionally evaluated LaABCB1, a multidrug resistance (MDR)-type ABC transporter strongly expressed in the secretory cells of lavender glandular trichomes, where monoterpene essential oil constituents are synthesized and secreted. We used LaABCB1 to complement a yeast knockout mutant in which 16 ABC transporters were deleted. Expression of LaABCB1 enhanced tolerance of yeast mutants to geraniol, a key constituent of essential oils in lavenders and numerous other plants. Our findings suggest a role for the MDR-type ABC transporters in the toxicity tolerance of at least certain essential oil constituents in lavender oil glands.
- Subjects
ATP-binding cassette transporters; MONOTERPENES; ESSENTIAL oils; LAVENDERS; EFFECT of poisons on plants; GENE expression in plants; PLANT genes; TRICHOMES
- Publication
Planta: An International Journal of Plant Biology, 2019, Vol 249, Issue 1, p139
- ISSN
0032-0935
- Publication type
Article
- DOI
10.1007/s00425-018-3064-x